Editorial Comment

Abstract

These authors have conducted an analysis of testosterone (T) levels in men with urethral stricture disease. Their results are very provocative insofar as demonstrating a clear link between hypoandrogenism (defined as <300 ng/dL) and longer stricture length. As these investigators note, there are no putative pathophysiologic mechanisms for stricture development. While there are some limitations to this research, like only 1 serum T draw and lack of a central laboratory, this work augments the previous observations by this group linking a low T with risk of artificial sphincter erosion.