Abstract
Editorial: Biomarkers of Alzheimer's Disease: The Present and the Future.
Highlights
Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders, and loss of functional autonomy
AD represents the major cause of dementia and has become a major public health issue
New revised AD diagnostic criteria include alteration of cerebrospinal fluid (CSF) biomarkers: a decrease in concentrations of amyloid peptides (Aβ42) and an increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for diagnosis of AD is a major step toward the “molecular” diagnosis and follow-up of the disease
Summary
Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders, and loss of functional autonomy. In the last two chapters, which focus on CSF and blood biomarkers, the different articles by Steen Jensen, Paquet, Lopez-Font, Zhao, Herbert, Inekci, Delaby, Fiandaca, and Baird propose new biomarkers such as plasma proteins of amyloid pathology, miRNA, cytokines, kinases, axonal proteins, lipids, and fragments of already known markers These articles give valuable insight into the novel approaches which could result in the identification of biomarkers useful in the field of diagnosis or therapeutic trials. CSF biomarkers are increasingly implemented in clinical routine to sustain the diagnosis of dementias knowing that there is a strong need for accurate, sensitive, and reliable biomarkers for AD This will help early diagnosis, targeted therapeutics, prognosis, and follow-up of patients. We are pleased that the current research topic gives a comprehensive state of the art of the use of the biomarkers, and projects good faith into the implementation of well-validated novel biomarkers for dementia in the future
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