Abstract
The fornix is a white matter bundle that connects the hippocampus with other limbic structures. It appears in the literature as early as 1543 in a historical publication of De Humani Corporis Fabrica by Andreas Vesalius (Swanson, 2014). The fornix is important for episodic memory recall (Tsivilis et al., 2008), which is impaired in Alzheimer's disease (AD). Alterations in the fornix were first observed in post-mortem AD brains (Hopper and Vogel, 1976). This volume focuses on the role of the fornix, and other limbic fibers, in the disease mechanisms of AD with some attention to how this might be applied in clinical practice.
Highlights
The fornix is a white matter bundle that connects the hippocampus with other limbic structures
The fornix is important for episodic memory recall (Tsivilis et al, 2008), which is impaired in Alzheimer’s disease (AD)
This volume focuses on the role of the fornix, and other limbic fibers, in the disease mechanisms of AD with some attention to how this might be applied in clinical practice
Summary
The fornix is a white matter bundle that connects the hippocampus with other limbic structures. The observation of limbic fibers in vivo forms a basis for understanding normal anatomy and alterations caused by various diseases. The limbic fibers are known to connect the structures of the default mode network (DMN), but the development of these fibers is less well understood. The fornix is among the white matter structures that mature early during development.
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