Abstract
Objective To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. Methods Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Bone marrow and soft tissue edema were defined on T2WI with fat suppression on MRI in all cases. The incidence rate of edema in benign tumors and tumor-like diseases was determined using the χ2 test. The preoperative diagnoses were reviewed, and the effect of edema on the differential diagnosis of benign and malignant tumors was analyzed. Results The incidence rate of bone marrow and soft tissue edema associated with benign tumors and tumor-like diseases was 35.7% (107/300), including 84.4% (27/32) Langerhans cell histiocytosis, 86.4% (19/22) osteoblastoma, 93.9% (31/33) osteoid osteoma, and 85.2% (23/27) chondroblastoma cases. There was no statistically significant difference in the incidence of edema among the four diseases (χ2 = 1.7, P > 0.05). Of 107 cases associated with edema, 49 (45.8%) were misdiagnosed as malignant tumors by MRI preoperatively. Conclusion Bone marrow and soft tissue edema are a common finding associated with benign bone tumors and tumor-like diseases, and they are frequently detected in Langerhans cell histiocytosis, osteoblastoma, osteoid osteoma, and chondroblastoma.
Highlights
Bone marrow and so tissue edema are a common nding associated with benign bone tumors and tumor-like diseases, and they are frequently detected in Langerhans cell histiocytosis, osteoblastoma, osteoid osteoma, and chondroblastoma
We retrospectively reviewed pathologically proven benign bone tumors and tumor-like diseases to explore the occurrence rate and characteristics of edema surrounding these lesions
Occurrence Rate of Surrounding Edema in Benign Bone Tumors and Tumor-Like Diseases. e results of the study by Kroon et al [11] showed that surrounding bone marrow edema and so tissue edema are detected in 42% (10/24) and 58% (14/24) of benign bone tumors and tumor-like diseases, respectively, which was a higher rate than that of the present study at 35.7% (107/300)
Summary
To explore the incidence and signi cance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. E incidence rate of edema in benign tumors and tumor-like diseases was determined using the 2 test. E preoperative diagnoses were reviewed, and the e ect of edema on the di erential diagnosis of benign and malignant tumors was analyzed. E incidence rate of bone marrow and so tissue edema associated with benign tumors and tumor-like diseases was 35.7% (107/300), including 84.4% (27/32) Langerhans cell histiocytosis, 86.4% (19/22) osteoblastoma, 93.9% (31/33) osteoid osteoma, and 85.2% (23/27) chondroblastoma cases. Of 107 cases associated with edema, 49 (45.8%) were misdiagnosed as malignant tumors by MRI preoperatively
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