Abstract
BACKGROUND: Head injury's potential role as a factor in the development of brain tumors has often been a controversial subject. MATERIALS AND METHODS: We performed a systematic literature search in the PubMed database. Eight full-text articles including eleven case reports were selected for critical reading. RESULTS: Of the 11 case reports studied, 4 (36%) patients were female with a mean age of 51 and 7 (64%) patients were male with a mean age of 49. All patients previously experienced a motor-vehicle accident that resulted in severe brain trauma. Men usually reported their symptoms (an average of 13 years after the accident) later that women (an average of 7 years after the accident). The most commonly presented symptoms were headache in 5 (45%) cases, seizures in 4 (36%)cases, and speech disturbance in 3 (37%) cases. CONCLUSION: Evidently, a connection between head trauma and the formation of glioma may exist, but further evaluation and study is required for a more definitive
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