Abstract
Biochemical changes in mouse livers infected with large intravenous inocula of ectromelia virus or regenerating after partial hepatectomy are described. Water content was unchanged and lipid content was increased in both infection and regeneration. In one or more of the experimental conditions, changes were observed in the activities of the following enzymes: succinic dehydrogenase, xanthine dehydrogenase, uricase, and acid phosphatase. The earliest change observed was an increase in xanthine dehydrogenase activity occurring before the appearance of new virus. The significance of these findings was discussed.
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