Abstract
Introduction: Gorham-Stout disease is a rare idiopathic condition of the bone that is characterized by a massive and spontaneous osteolysis, with a vascular or lymphatic proliferation in bone, which is then replaced by fibrous tissue. Observation: a 16-year-old patient was referred to the maxillofacial surgery department to remove ectopic teeth bilaterally in the ramus. He had Gorham-Stout disease, managed for many years in orthopedic surgery department for a lower limb lesion and in neurosurgery department for a breach of the meninges. He was treated for 4 years with bisphosphonates. The removal of the ectopic teeth went well, with a simple postoperative course. Discussion: Gorham-Stout disease physiopathology remains unknown. Facial bones are often involved, especially the mandible. There are many possible treatments, but, due to the rarity of the disease, no therapeutic consensus exists. Bisphosphonates seem to be a good way to control this condition. So far, no case of bisphosphonates related osteonecrosis of the jaw has been reported in children. Conclusion: Gorham-Stout disease can involve the mandible and may lead to ectopic teeth.
Highlights
Gorham–Stout disease (GSD), known as Gorham’s disease or vanishing bone disease, is a rare osseous condition that is characterized by massive, spontaneous osteolysis, with blood or lymphatic vessel proliferation in the bone, which is subsequently replaced by fibrous tissue [1,2,3,4,5]
A 16-year-old male with GSD was referred to the department of maxillofacial surgery for the management of mandibular retrognathia that was causing sleep apnea
GSD is a rare disease that frequently affects the facial region and can result in mobility, ectopia, and loss of teeth as well as progressive bone lesions that can lead to the complete disappearance of the bone
Summary
Gorham–Stout disease (GSD), known as Gorham’s disease or vanishing bone disease, is a rare osseous condition that is characterized by massive, spontaneous osteolysis, with blood or lymphatic vessel proliferation in the bone, which is subsequently replaced by fibrous tissue [1,2,3,4,5]. GSD involves the idiopathic and progressive osteolysis of one or more contiguous bones surrounding an initial site, regardless of the sutures. This disease can affect any skeletal bone, it is most frequently reported in the skull, shoulders, and pelvic girdle [2]. According to the orthodontic consultation, it was decided to remove the ectopic teeth and persistent temporary teeth The patient and his patients were informed regarding the surgical risks involved (mandibular fracture risk and nerve risk), and his parents provided their consent for the procedure. The operation was successful, and no postoperative complications were observed (Figs. 4 and 5)
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