Abstract

We describe a patient with widespread metastatic carcinoma of the prostate in whom radiotherapy failed and orchiectomy was performed, after which symptoms of Cushing's syndrome developed as a result of ectopic secretion of adrenocorticotropic hormone (ACTH) by the tumor. The patient was treated with high oral doses of ketoconazole. The effects of ketoconazole on the clinical and laboratory manifestations of ectopic ACTH syndrome and a review of this subject are presented.

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