Abstract
Acromegaly is habitually caused by a pituitary growth hormone (GH)-secreting adenoma, resulting in elevated circulating levels of GH and insulinlike growth factor-1 (IGF-1). Ectopic acromegaly is of very rare occurrence, accounting for less than 1% of clinical acromegaly. This entity is more often than not related to a pancreatic or bronchial GH-releasing hormone (GH-RH) producing neuroendocrine tumor, which is responsible for a nonadenomatous hyperplasia of the pituitary somatotrophic cells. The authors report 2 cases of successful detection of a GH-RH-secreting tumor by In-111 pentetreotide scintigraphy, one in a lung and the other in the pancreas.
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