“Ectopic acanthosis nigricans” in inguinal skin grafted to the hands of a child

Abstract

Acanthosis nigricans (AN) is a skin disorder characterized by hyperpigmentation and hyperkeratosis and is associated with an underlying disease or condition.1Brady M.F. Rawl P. Acanthosis nigricans.in: StatPearls. StatPearls Publishing, 2021Google Scholar It appears as dark, coarse, thick, and velvety plaques, usually in intertriginous areas, such as the groin, axilla, and neck folds.1Brady M.F. Rawl P. Acanthosis nigricans.in: StatPearls. StatPearls Publishing, 2021Google Scholar,2Das A. Datta D. Kassir M. et al.Acanthosis nigricans: a review.J Cosmet Dermatol. 2020; 19: 1857-1865https://doi.org/10.1111/jocd.13544Google Scholar The pathophysiology of AN is multifactorial, resulting in proliferation of epidermal keratinocytes and dermal fibroblasts.2Das A. Datta D. Kassir M. et al.Acanthosis nigricans: a review.J Cosmet Dermatol. 2020; 19: 1857-1865https://doi.org/10.1111/jocd.13544Google Scholar The resultant histopathological changes include epidermal acanthosis with papillomatosis, hyperkeratosis, mild increase in pigmentation, with a pauci-inflammatory dermis.2Das A. Datta D. Kassir M. et al.Acanthosis nigricans: a review.J Cosmet Dermatol. 2020; 19: 1857-1865https://doi.org/10.1111/jocd.13544Google Scholar,3Sinha S. Schwartz R.A. Juvenile acanthosis nigricans.J Am Acad Dermatol. 2007; 57: 502-508https://doi.org/10.1016/j.jaad.2006.08.016Google Scholar Multiple classification systems exist to describe this condition.2Das A. Datta D. Kassir M. et al.Acanthosis nigricans: a review.J Cosmet Dermatol. 2020; 19: 1857-1865https://doi.org/10.1111/jocd.13544Google Scholar Skin grafts are often required in burn patients for reconstruction. This is performed using split-thickness skin grafts or full-thickness skin grafts (FTSGs), depending on the anatomic area of reconstruction.4Moon S.-H. Lee S.-Y. Jung S.-N. et al.Use of split thickness plantar skin grafts in the treatment of hyperpigmented skin-grafted fingers and palms in previously burned patients.Burns. 2011; 37: 714-720https://doi.org/10.1016/j.burns.2011.01.010Google Scholar Hyperpigmentation following grafting in burn patients is not uncommon5Kubota Y. Mitsukawa N. Chuma K. et al.Hyperpigmentation after surgery for a deep dermal burn of the dorsum of the hand: partial-thickness debridement followed by medium split-thickness skin grafting vs full-thickness debridement followed by thick split-thickness skin grafting.Burn Trauma. 2016; 4: 1-11https://doi.org/10.1186/s41038-016-0039-7Google Scholar and occurs due to excessive accumulation of melanin resulting from increased melanogenic activity of melanocytes in the basal layer of the epidermis.6Tsukada S. The melanocytes and melanin in human skin autografts.Plast Reconstr Surg. 1974; 53: 200-207https://doi.org/10.1097/00006534-197402000-00012Google Scholar The following report describes a young boy with burns to the palms of both hands who required skin grafting for reconstruction. Initially thought to have conventional hyperpigmentary changes in his skin grafts, biopsy later revealed features consistent with AN. A 2-year-old boy with a past medical history of a solitary kidney sustained deep partial- and full-thickness burns to both palms after falling into a fire pit. The wounds were initially dressed with Flamazine (Smith & Nephew) until subsequent eschar debridement, and his dressings switched to daily antibiotic ointment and Jelonet (Smith & Nephew). After 2 weeks, he was noted to have complete re-epithelization of most burns, apart from those over the ulnar aspect of the hands. He was discharged home with close follow-up. Complete re-epithelization, including the ulnar aspect of the hands, occurred by 1 month post burn. He eventually developed contractures along his left long, ring and small fingers and his right small finger, which led to surgical release of these contractures with Z-plasties 1 year following his initial injury. He developed further contractures during periods of rapid hand growth. His contractures began interfering with function 4 years after the initial burn, necessitating further surgical release. The patient underwent repeat scar excision with coverage of the resulting skin defects using FTSG harvested from the inguinal crease. He was noted to have 100% take of his grafts in follow-up visits. They were initially noted to be violaceous, in keeping with normal early graft appearance. There were early signs of hyperpigmentation and hyperkeratosis 1 month later, which appeared well developed on the palmar aspects of the skin grafts by 2 months after surgery (Fig 1). The hyperpigmentation worsened over several follow-up appointments, resulting in dermatology consultation 1.5 years after skin grafting (6 years following initial injury). Topical 0.5% clobetasol cream was trialed but did not improve the appearance. He was noted to have recurrence of his flexion contractures and was experiencing emotional distress due to the hyperpigmentation in follow-up 3.5 years after skin grafting (8 years after the initial injury). As such, excision of the previous skin graft from the left palm was performed. To cover the residual skin defect, an FTSG was planned. It was harvested from the left forearm in hopes of avoiding the previously noted hyperpigmentation observed with the inguinal crease-derived grafts. Intraoperatively, during tangential excision of the previous grafts, the epithelial layer was noted to be friable, thick, and easily separated from the underlying graft dermis. Suspicion arose at this point that the dark color of the grafts could be attributable to acanthosis nigricans. Histopathological examination of the old graft tissue revealed epidermal papillomatosis, hyperkeratosis, and mild basal hyperpigmentation (Fig 2). The epidermal changes were beyond those expected in conventional skin graft hyperpigmentation and were consistent with features of “ectopic AN.” The patient did not have any evidence of AN elsewhere on his body. Historically, AN has been clinically classified via multiple systems. Curth7Curth H.O. Classification of acanthosis nigricans.Int J Dermatol. 1976; 15: 592-593https://doi.org/10.1111/j.1365-4362.1976.tb04895.xGoogle Scholar first described AN as benign, malignant, obesity-associated (pseudo-AN), or syndromic. Hernandez-Pérez8Hernández-Pérez E. On the classification of acanthosis nigricans.Int J Dermatol. 1984; 23: 605-606https://doi.org/10.1111/j.1365-4362.1984.tb05698.xGoogle Scholar simplified classification, distinguishing paraneoplastic AN from simple AN of various subtypes. Burke et al9Burke J.P. Hale D.E. Hazuda H.P. Stern M.P. A quantitative scale of acanthosis nigricans.Diabetes Care. 1999; 22: 1655-1659https://doi.org/10.2337/diacare.22.10.1655Google Scholar created a scale that classified AN according to the severity based on the number of affected sites. Sinha and Schwartz3Sinha S. Schwartz R.A. Juvenile acanthosis nigricans.J Am Acad Dermatol. 2007; 57: 502-508https://doi.org/10.1016/j.jaad.2006.08.016Google Scholar differentiated AN into 8 different types (Table I) including obesity associated, syndromic, medication induced, malignant, acral, unilateral, benign AN, and mixed type.Table IClassification of acanthosis nigricans as described by Sinha and Schwartz3Sinha S. Schwartz R.A. Juvenile acanthosis nigricans.J Am Acad Dermatol. 2007; 57: 502-508https://doi.org/10.1016/j.jaad.2006.08.016Google ScholarType of acanthosis nigricans3Sinha S. Schwartz R.A. Juvenile acanthosis nigricans.J Am Acad Dermatol. 2007; 57: 502-508https://doi.org/10.1016/j.jaad.2006.08.016Google ScholarFeatures and findings2Das A. Datta D. Kassir M. et al.Acanthosis nigricans: a review.J Cosmet Dermatol. 2020; 19: 1857-1865https://doi.org/10.1111/jocd.13544Google Scholar,3Sinha S. Schwartz R.A. Juvenile acanthosis nigricans.J Am Acad Dermatol. 2007; 57: 502-508https://doi.org/10.1016/j.jaad.2006.08.016Google ScholarObesity associated•Most common in children and adults•Insulin and insulin-like growth factor (IGF) are the stimulants for the proliferation of epidermal keratinocytes and dermal fibroblastsSyndromic•Type A insulin resistance syndrome (HAIR-AN syndrome), type B insulin resistance syndrome, Crouzon’s syndrome, gigantism, acromegaly, and Prader-Willi syndromeMedication induced•Most associated with nicotinic acid.•Other implicated medications include oral contraceptives, corticosteroids, methyl-testosterone, heroin, fusidic acid, hydantoin-like derivatives, and diethylstilbestolMalignant•Cutaneous manifestation of an underlying malignancy•Rare in pediatric population•Gastric adenocarcinoma is the most commonAcral•Affects the knuckles, elbows, and kneesUnilateral•Epidermal nevoid condition•May eventually become bilateralBenign•Rare, may be inherited in an autosomal dominant fashion with variable penetrance•Can either be congenital or develop in childhood or during adolescence•Palms of the hands and soles of the feet are usually spared•No underlying malignancy or metabolic derangementMixed type•Consists of multiple subtypes Open table in a new tab To our knowledge, no other case report has documented the occurrence of AN in skin grafts on the volar aspect of the hand, and this report is only the second to describe AN on the hand after skin grafting. Previously, Wu and Cunningham10Wu J.C. Cunningham B.B. Ectopic acanthosis nigricans occurring in a child after syndactyly repair.Cutis. 2008; 81: 22-24Google Scholar described a case of a 12-year-old boy who developed AN following FTSG from the groin to repair bilateral syndactyly. In that case, the patient had a past medical history significant for exogenous obesity, nonalcoholic steatohepatitis, dyslipidemia, and insulin resistance. In contrast, our patient did not have any identifiable predisposing factors that would be associated with AN. Specifically, he was not obese and had no evidence of insulinemia, took no AN-associated medication, exhibited bilateral involvement, and had no known AN-associated syndrome. Although our patient’s AN occurred on his hands, the involved skin was derived from the groin. Additionally, unlike acral AN, the AN observed involved the volar aspect and not the dorsal (knuckle) of the hand. While his past medical history was significant for a solitary kidney, there is no documented association between this and AN development. Additionally, there was no family history of AN. As such, it is challenging to classify the subtype of AN in our case. Surgeons and dermatologists should be aware of this exceptionally rare complication of skin grafting and should consider AN on their differential when observing hyperpigmentation in skin grafts. In such cases, clinical follow-up is advisable to monitor for other signs of insulin resistance or other conditions associated with AN. In summary, this case report documents the occurrence of ectopic acanthosis nigricans in a skin graft used to resurface the volar aspect of a hand after burn injury. Clinicians should be suspicious of AN in cases of hyperpigmentation post skin grafting that does not respond to traditional treatments and measures. None disclosed.