Abstract
Background and Aims: Plasma levels of low-density lipoprotein cholesterol (LDL-C) are positively correlated with risk of atherosclerosis. LDL receptor (LDLR) is mainly resposible for LDL-C clearance. LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. Plasma sLDLR levels are positively correlated with plasma LDL-C levels. However, the proteinase responsible for LDLR cleavage is unknown. Membrane type 1-matrix metalloproteinase (MT1-MMP) is a Zn2+-dependent endopeptidase that can cleave extracellular matrix and non-matrix substrates.
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