Abstract
We formulate a model that determines the net benefit of Johne's disease vaccination within a tuberculosis‐accredited region given the extra costs associated with the vaccine‐related cross‐reactivity with tuberculosis test results and the probability of a tuberculosis outbreak. We apply the model to Minnesota and Michigan, where tuberculosis has recently become endemic. The expected benefit of Johne's vaccination of $53.03 per cow exceeds the cost of Johne's cross‐reactivity of $32.72 and $32.42 per cow within each of the two Minnesota tuberculosis regions, as well as $31.99 and $30.78 per cow within each of the two Michigan tuberculosis regions.
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