Abstract
BackgroundThe emerging highly pathogenic avian influenza strain H5N1 ("HPAI-H5N1") has spread broadly in the past decade, and is now the focus of considerable concern. We tested the hypothesis that spatial distributions of HPAI-H5N1 cases are related consistently and predictably to coarse-scale environmental features in the Middle East and northeastern Africa.We used ecological niche models to relate virus occurrences to 8 km resolution digital data layers summarizing parameters of monthly surface reflectance and landform. Predictive challenges included a variety of spatial stratification schemes in which models were challenged to predict case distributions in broadly unsampled areas.ResultsIn almost all tests, HPAI-H5N1 cases were indeed occurring under predictable sets of environmental conditions, generally predicted absent from areas with low NDVI values and minimal seasonal variation, and present in areas with a broad range of and appreciable seasonal variation in NDVI values. Although we documented significant predictive ability of our models, even between our study region and West Africa, case occurrences in the Arabian Peninsula appear to follow a distinct environmental regime.ConclusionOverall, we documented a variable environmental "fingerprint" for areas suitable for HPAI-H5N1 transmission.
Highlights
The emerging highly pathogenic avian influenza strain H5N1 ("HPAI-H5N1") has spread broadly in the past decade, and is the focus of considerable concern
In almost all tests, HPAI-H5N1 cases were occurring under predictable sets of environmental conditions, generally predicted absent from areas with low Normalized Difference Vegetation Index (NDVI) values and minimal seasonal variation, and present in areas with a broad range of and appreciable seasonal variation in NDVI values
Most of the 9 tests conducted as part of this study indicated that independent test points coincided with ecological niche models (ENMs) predictions significantly better than random expectations, not without exceptions
Summary
The emerging highly pathogenic avian influenza strain H5N1 ("HPAI-H5N1") has spread broadly in the past decade, and is the focus of considerable concern. Between May and June 2005, >6000 birds of 8 wild waterbird species were found dead at Qinghai Lake, in central China: HPAI-H5N1 was detected in 15 birds of 6 wild species [7], some migratory, fueling fears of broader spread [8]. This event apparently marked a turning point in the spread of the virus: by early (page number not for citation purposes)
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