Abstract

An efficient method for the synthesis of α-aminonitriles via one-pot three-component condensation of ketones, amines and potassium hexacyanoferrate(II) using benzoyl chloride as a promoter and PEG-400 as a reaction medium was described. This protocol has the features of use of eco-friendly cyanide source, green reaction medium, high yield, and simple work-up procedure.

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