Abstract
Condensation of 2-substituted-3,5-dichloroacetophenones 2a-c obtained from the condensation of 2-hydroxy-3,5-dichloroacetophenone 1 and benzoyl chloride were dissolved in NaOH , on treatment under baker venkatraman transformation in presence of KOH with pyridine gives 1-(2-hydroxy-3,5- dichlorophenyl )-3-substituted-1,3propanedione 3a-c. Then converted into 3–aroyl-6,8-dichloroflavanones 4a-i by using different aromatic aldehyde in the presence of ethanol, Piperidine. The condensation of 4a-i with crystal of iodine in DMF solvent gives 3-aroylflavone 5a-i. The condensation of 5a-i and phenylhydrazinehydrochlorides, piperidine in DMF gives 4-aroyl-3,5diarylpyrazoles 6a-i and condensation of 5a- i and hydroxylaminehydrochlorides gives 4aroyl–3,5diarylisoxazoles 7a –i. The above compounds are screened for their antimicrobial activities and have been found to exhibit significant antibacterial and antifungal activities. The zones of inhibition measured in term of mm.
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