Abstract
K2CO3–Al2O3 has been used as an efficient, eco-friendly, and cost-effective activating catalyst for the synthesis of 3-(2-chloroquinolin-3-yl)-1-substituted phenyl prop-2-en-1-ones starting from 2-chloroquinoline-3-carbaldehyde and acetophenone. The reactions were performed under ultrasound irradiations. A substantial enhancing effect in the yield was observed when the catalyst was activated under ultrasonic waves. The K2CO3–Al2O3 catalyst can compete with the traditional NaOH/MeOH system of catalysis when the reaction is carried out under ultrasound. Herein, a benign, eco-friendly, efficient, and extremely fast procedure for the synthesis of quinoline chalcones has been demonstrated successfully.
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