Eco-friendly Approach: Graphene Like Boron Nitride Modified Calcium Material For The Synthesis Of 2-amino-4H-pyran-3-carbonitrile Derivatives

Abstract

An efficient one-pot multi-component synthesis of medicinally important 2-amino-4H-pyran-3-carbonitrile derivatives using a new heterogeneous calcium loaded boron nitride (CaBNT) catalyst is described herein. This transformation transpires by Knoevenagel condensation, Michael addition and intramolecular cyclization. Alkaline earth metal-based green catalyst was successfully prepared and characterized by XRD, SEM with EDX, Raman spectroscopy, BET, DSC-TGA and FT-IR. The reaction works up is facile and CaBNT catalyst can easily be separated from the reaction mixture and re-used more than five times in subsequent reactions. This methodology offers several advantages such as excellent yields, use of inexpensive solvent and relatively shorter reaction time.