Abstract
The DNA of bacteriophage SPO1, which is normally infective for competent Bacillus subtilis, is modified after phage infection so as to render it noninfective. Infective DNA reappears in phage-infected cells shortly after the onset of viral DNA replication. This eclipse of infectivity is correlated with the appearance of single-strand breaks in the infecting viral DNA, which are repaired to some extent by by the time of reappearance of infectivity.
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