Abstract
Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eckol isolated from the marine brown algae, Ecklonia cava using immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMC) and a mouse model of anaphylaxis. Eckol inhibited IgE/BSA-induced BMCMC degranulation by reducing β-hexosaminidase release. A flow cytometric analysis revealed that eckol decreases FcεRI expression on cell surface and IgE binding to the FcεRI in BMCMC. Moreover, eckol suppressed the production of the cytokines, interleukin (IL)-4, IL-5, IL-6, and IL-13 and the chemokine, thymus activation-regulated chemokine (TARC) by downregulating, IκB-α degradation and NF-κB nuclear translocation. Furthermore, it attenuated the passive cutaneous anaphylactic reaction induced by IgE/BSA-stimulation in the ear of BALB/c mice. These results suggest that eckol is a potential therapeutic candidate for the prevention and treatment of allergic disorders.
Highlights
Marine algae are consumed by humans and used as medicinal sources owing to their biochemical properties and relative abundance [1,2,3]
Our results suggest that the inhibitory effect of eckol on both immunoglobulin E (IgE) and FcεRI expression effectively leads to the suppression of IgE-mediated allergic responses in IgE/bovine serum albumin (BSA)-mediated passive cutaneous anaphylaxis (PCA) mice
The results of this study demonstrated that eckol has antiallergic effects in IgE/BSA-stimulated
Summary
Marine algae are consumed by humans and used as medicinal sources owing to their biochemical properties and relative abundance [1,2,3]. Brown algae (including Ecklonia species) have been investigated extensively as they contain phlorotannins, which possess various physiological properties. Ecklonia cava, brown algae in the family Lessoniaceae are characterized by abundant eckol-type phlorotannins [2,3,4]. Nutrients 2020, 12, 1361 and red algae This compound is a trimer of phloroglucinol and has been reported to possess antioxidant [5,6,7,8,9,10], anti-inflammatory [11,12], anticancer [13,14], antihepatic [10] activities, as well as inhibitory effects on acetylcholine esterase [15] and protective effects against skin damage [16]. The antiallergic effects of eckol in immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated bone marrow-derived cultured mast cells (BMCMC) and a passive cutaneous anaphylaxis (PCA)
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