Abstract
The percutaneous MitraClip system is recognized as a valuable alternative to surgery in patients with symptomatic mitral regurgitation (MR) and prohibitive surgical risk. However, the MitraClip procedure may lead to a reduction in the mitral valve orifice area (MVOA) and increased transmitral mean gradients (TMG). Although preprocedural MVOA≤4 cm2 is considered a relative contraindication for the procedure; predictors of post-intervention TMG are not well known and TMG is also influenced by transvalvular flow. The objectives of this study are to assess the value of baseline MVOA by different imaging methods and explore the value of MVOA indexed for left ventricular forward stroke volume (SV) to predict post-intervention TMG.
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