Abstract
Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with sudden onset of ventricular fibrillation of unidentified origin. New diagnostic tools that can detect subtle abnormalities are needed to diagnose and treat patients with an underlying substrate. The purpose of this study was to explore echocardiographic deformation characteristics in IVF patients. Echocardiograms were analyzed with deformation imaging by 2-dimensional speckle tracking. Global and regional measurements of the left ventricle (LV) and right ventricle (RV) were performed. Regional LV deformation patterns were evaluated for the presence of postsystolic shortening. Regional RV deformation patterns were classified as type I (normal) or type II/III (abnormal). In total, 47 IVF patients (mean age 45 years; left ventricular ejection fraction [LVEF] 56%) and 47 healthy controls (mean age 41 years; LVEF 60%) were included. IVF patients showed more global deformation abnormalities as indicated by lower LV global longitudinal strain (18.5% ± 2.6% vs 21.6% ± 1.8%; P <.001) and higher LV mechanical dispersion (41 ± 12 ms vs 26 ± 6 ms; P <.001). In addition, IVF patients showed more regional LV postsystolic shortening compared to healthy controls (50% vs 11%; P <.001). Abnormal RV deformation patterns were observed in 16% of IVF patients and in none of the control subjects (P <.001). We were able to show both regional and global echocardiographic deformation abnormalities in IVF patients. This study provides evidence that localized myocardial disease is present in a subset of IVF patients.
Highlights
Idiopathic ventricular fibrillation (IVF) has been diagnosed in patients with sudden onset of ventricular fibrillation (VF), the origin of which is not identified after extensive diagnostic testing.[1]
IVF patients showed more global deformation abnormalities as indicated by lower left ventricle (LV) global longitudinal strain (18.5% 6 2.6% vs 21.6% 6 1.8%; P,.001) and higher LV mechanical dispersion (41 6 12 ms vs 26 6 6 ms; P,.001)
IVF patients showed more regional LV postsystolic shortening compared to healthy controls (50% vs 11%; P,.001)
Summary
Idiopathic ventricular fibrillation (IVF) has been diagnosed in patients with sudden onset of ventricular fibrillation (VF), the origin of which is not identified after extensive diagnostic testing.[1] the diagnosis of IVF depends on the absence. Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with sudden onset of ventricular fibrillation of unidentified origin. New diagnostic tools that can detect subtle abnormalities are needed to diagnose and treat patients with an underlying substrate
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have