Abstract
Electrical stimulation of diencephalic and mesencephalic loci, in both dogs and cats, elicited a spectrum of ventricular arrhythmias which frequently persisted for 5 minutes or longer after the offset of the stimulus. Intravenous administration of 10 mg. per kilogram of diphenylhydantoin sodium not only abolished these ectopic ventricular rhythms, but also prevented their induction by a subsequent stimulus for periods varying from 30 minutes to 7 hours. A possible central nervous system action for the drug is suggested.
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