Eccrineporocarcinoma of thigh : A rare adnexal tumour

Nikhil U Ningurkar,Shivraj N Kanthikar,Nandkumar V Dravid,Dhiraj B Nikumbh,Arundhati S Gadre

doi:10.21276/apalm.1713

Nikhil U Ningurkar, Shivraj N Kanthikar + Show 3 more

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https://doi.org/10.21276/apalm.1713

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Abstract

We report a rare case of eccrine porocarcinoma (EPC) in a 65 year old male patient. EPC arises from the intraepidermal portion of the eccrine sweat glands (acrosyringium). Previously the tumour was known as eccrine adenocarcinoma or malignant eccrine poroma with incidence predominantly in extreme of old age. The tumour arises most commonly on hands and feet. Rare sites like scalp, face, penis and abdomen are also reported in the literature. The distinction of porocarcinoma and basal cell carcinoma can be a diagnostic dilemma on a superficial biopsy. The histological features of high mitotic rate, tumour depth and lymphovascular invasion are bad prognostic markers. Immunohistochemistry for CK15, CK7, epithelial membrane antigen (EMA) and estrogen confirmed the diagnosis of EPC. This tumour is preferably treated with Moh’s surgery though few cases of metastasis are reported. DOI:10.21276/APALM.1713

Highlights

Eccrine porocarcinoma (EPC) is a cutaneous adnexal neoplasm
EPC is very rare tumour with incidence ranging from 0.005% to 0.01% of all cutaneous neoplasm. [1,2] It is seen in the age group 60-80 years with female predominance.[1,2]
We report a 65 year old male patient with EPC that developed on right thigh

Summary

Introduction

Eccrine porocarcinoma (EPC) is a cutaneous adnexal neoplasm. Cutaneous adnexal neoplasms are varied group of neoplasm with most challenging areas of dermatopathology. The surgeons sent in a superficial biopsy to our department with a clinical diagnosis of basal cell carcinoma. On histopathological examination the biopsy revealed a palisading arrangement in a focal area with cells originating from the epidermis. With the atypical appearance of the malignant cells the patient was advised for a resection of the tumour in suspicion of a variant of basal cell carcinoma. On close examination few cystic areas were noted in the superficial region along with infiltration of the tumour in the subcutaneous region (Fig. 1C, 1D). On histopathological examination the tumour revealed atypical poroid cells infiltrating into dermis as anatomizing bands and dermal tumour infiltrate (Fig. 2A).

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