Abstract

Eccrine porocarcinoma (EPC) is an extremely rare, adnexal carcinoma that represents less than 0.01% of all cutaneous malignancies. An aggressive tumour with a high recurrence rate, it has a tendency to metastasise to regional lymph nodes. Once metastasis has occurred, mortality rate increases to 75%-80% and thus survival is dependent on adequate and timely resection of the lesion. EPCs are frequently missed as a differential diagnosis due to their rarity and non-specific appearance, which can lead to serious consequences for patients. Consequently, EPCs are an important diagnosis for clinicians to be aware of and consider when evaluating cutaneous lesions. We present a case of EPC of the knee, which was initially misdiagnosed as a benign lesion on magnetic resonance imaging (MRI). We discuss the use of MRI in aiding assessment of EPCs.

Highlights

  • Malignant cutaneous adnexal neoplasms are broadly divided into four groups of eccrine, apocrine, mixed, and un-classified tumours

  • Eccrine porocarcinoma (EPC) is an extremely rare, adnexal carcinoma that represents less than 0.01% of all cutaneous malignancies

  • EPCs are frequently missed as a differential diagnosis due to their rarity and non-specific appearance, which can lead to serious consequences for patients

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Summary

Introduction

Malignant cutaneous adnexal neoplasms are broadly divided into four groups of eccrine, apocrine, mixed, and un-classified tumours. Eccrine porocarcinoma (EPC), first described by Pinkus and Mehregan in 1963, is a rare type of adnexal carcinoma which accounts for less than 0.01% of all cutaneous malignancies [1,2,3] It can present as a nodular, erosive plaque or polypoid growth that ulcerates. On re-presentation, the mass had increased in size and the patient was referred back to the plastic surgery department This time, the lesion was excised and sent for histology. A. Axial MRI of the right knee with gadolinium contrast showing a subcutaneous mass (see arrow) on the anterior aspect of the tibia and knee joint. Axial MRI of the right knee with gadolinium contrast showing a subcutaneous mass (see arrow) on the anterior aspect of the tibia and knee joint It consists of a large loculated mass containing some debris inferiorly, lying superficial to and separate from the infrapatellar tendon. The patient was regularly reviewed in the clinic until full wound healing was achieved and discharged to primary care with planned annual follow-up appointments for five years

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