Abstract
The Directive which lays down the principles for the assessment of the risks to man and the environment of new chemical substances specifies four distinct stages in a risk assessment: hazard identification, dose (concentration)-response (effect) assessment, exposure assessment and risk characterization. The central principle is that risk is dependent upon the likely extent of exposure to a substance as well as its inherent hazardous properties. An assessment should lead to one (or more) of four conclusions: that a substance is of no immediate concern, that risk reduction recommendations should be made, that additional information should be obtained immediately or that additional information should be obtained at a later stage. Additional information can be used to revise an assessment and to confirm indications of a given risk.
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