Abstract
BackgroundLymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Based on the limited number of case reports that exist, the association of Epstein–Barr virus (EBV) with primary thyroid LELCs seems inconsistent.Case presentationWe present a confusing cytological case of lymphoepithelioma-like thyroid carcinoma with expression of EBV. The patient presented with a central neck mass and bilateral lymphadenopathy. Fine-needle aspiration cytology revealed three-dimensional and syncytial fragments of epithelioid cells accompanied by small lymphocytes. The surgical specimen of resected thyroid tumor disclosed typical histopathological features of LELC. Metastatic papillary carcinoma was also discovered in the metastatic lymph nodes. In situ hybridization for EBV-encoded RNA (EBER-ISH) was positive in the tumor cells. Negative immunoreactivity for TTF-1, Pax-8, and CD5 was observed. The patient is currently undergoing regular follow-up and is 1 year and 10 months postresection with no evidence of recurrence.ConclusionsLong-term survival is discussed in relation to this variant of thyroid carcinoma, which might differ in behavior from anaplastic carcinoma. Further investigation is required to elucidate the clinical significance of EBV expression and progression of this unique variant of thyroid carcinoma.
Highlights
Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors
Long-term survival is discussed in relation to this variant of thyroid carcinoma, which might differ in behavior from anaplastic carcinoma
Further investigation is required to elucidate the clinical significance of Epstein–Barr virus (EBV) expression and progression of this unique variant of thyroid carcinoma
Summary
We reported a patient with an EBV-associated thyroid carcinoma exhibiting a characteristic LELC pattern. Both authors have read and approved the final manuscript. Bladder: a case report and systematic review for optimal treatment modality for disease-free survival. Primary lymphoepithelioma-like carcinoma of salivary glands: a clinicopathological study of 21 cases. Lymphoepithelioma-like carcinoma of cervix: cytological features on conventional cervical smear. Cytological findings of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: a study of eight cases. Thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis. Author details 1Division of Pathology, Sijhih Cathay General Hospital, No., Lane 59, Jiancheng Road, Sijhih District, New Taipei City 22174, Taiwan. Author details 1Division of Pathology, Sijhih Cathay General Hospital, No., Lane 59, Jiancheng Road, Sijhih District, New Taipei City 22174, Taiwan. 2Department of Pathology, Cathay General Hospital, Taipei, Taiwan. 3College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
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