Abstract
journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine.
Highlights
Epstein-Barr virus (EBV)-associated Gastric Carcinoma (EBVaGC) is defined by the presence of EBV in cancer cells, which is detected by EBVEncoded RNA (EBER) in situ hybridization
This type of tumor is a specific entity of gastric carcinoma based on molecular abnormality with favorable prognosis compared with conventional adenocarcinoma. histological hallmark such as marked intra- or peritumoral immune cell infiltration and positivity in the EBER in situ hybridization will be helpful in the diagnosis
EBV-associated gastric carcinoma (EBVaGC) is characterized by marked immune cell infiltration, and By Song et al, [5], which is classified into three histological subtype according to the cellular immune response affecting prognosis; lymphoepithelioma-like carcinoma (LELC), carcinoma with Crohn’s disease-like lymphphoid reaction (CLR), and conventional adenocarcinoma (CA)
Summary
This type of tumor is a specific entity of gastric carcinoma based on molecular abnormality with favorable prognosis compared with conventional adenocarcinoma. histological hallmark such as marked intra- or peritumoral immune cell infiltration and positivity in the EBER in situ hybridization will be helpful in the diagnosis. This type of tumor is a specific entity of gastric carcinoma based on molecular abnormality with favorable prognosis compared with conventional adenocarcinoma. Histological hallmark such as marked intra- or peritumoral immune cell infiltration and positivity in the EBER in situ hybridization will be helpful in the diagnosis. Abbrevations: EBVaGC: EBV-Associated Gastric Carcinoma; EBER: EBV-Encoded RNA; TCGA: The Cancer Genome Atlas; EBV: Epstein-Barr Virus; GCs: Gastric Carcinomas; CLR: Crohn’s Disease-like Lymphphoid Reaction; CA: Conventional Adenocarcinoma; TCGA: The Cancer Genome Atlas Research Network; PD-L: Programmed Death Receptor-Ligand; EGD: Esophagogastroduodenoscopy; CT: Computed Tomography; LELC: Lymphoepithelioma-like Carcinoma; TILs: Tumor-Infiltrating Lymphocytes; GRC: Gastric Remnant Carcinoma; LN: Lymph Node; TMIT 1: Tumor Microenvironment Immune Type 1; AI: Apoptosis Index
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