Abstract
Cryptococcal infection in humans most commonly appears as a disease of the central nervous system, and also causes disease of lung, bone, skin and rarely lymph nodes (LNs). We present a fine needle aspiration cytology of cryptococcal lymphadenitis in a 39-year-old female with a mass-like lesion in the lung and multiple LN enlargements. The patient was diagnosed as cryptococcosis in supraclavicular LN biopsy, and the diagnosis was reconfirmed by following endobronchial ultrasound (EBUS) transbronchial LN aspiration cytology. Her chest computed tomography (CT) scan showed the patchy consolidation about 3cm in diameter in the right lower lobe of the lung and multiple LN enlargements in both supraclavicular and mediastinal area. She had undergone US-guided aspiration biopsy of the supraclavicular LN and it turned out cryptococcal infection. Fiber optic bronchoscopy revealed no endobronchial lesion, but EBUS transbronchial LN aspiration cytology on enlarged mediastinal LN confirmed the yeast, consistent with Cryptococcus. Then, the patient responded well to the parenteral antifungal therapy. This is a rare case in a patient with pulmonary cryptococcosis and involvement of the supraclavicular LN.
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