Abstract
Ebselen is a lipid - soluble seleno - organic compound whose benefits have been shown in a variety of diseases and in experimental studies including anti - inflammation, anti - proliferation, anti angiogenesis, anti c arcinogenesis and anti - oxidation properties. This study aimed to evaluate the effect of ebselen against hypoxia - induced biological responses in human alveolar epithelial cells (A549 cells). Hypoxia treatment increased the generation of reactive oxygen spec ies, proinflammatory cytokines/chemokines, cell death and proliferation in A549 cells in a time dependent manner. Notably, Ebselen treatment significantly reduced the production of reactive oxygen species and levels of biochemical markers for lipid peroxid ation. Ebselen treatment increased the antioxidant enzyme superoxide dismutase activity as well. This seleno - organic compound also reduced the production of proinflammatory chemokines IL - 8 and proinflammatory cytokine TNF - α. It is worth noticing that, Ebse len enhanced the viability as well as proliferation of
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