Ebolavirus: Infection, Vaccination and Control

Abstract

Members of the genus Ebolavirus (family Filoviridae) are among the deadliest viral pathogens spread throughout the world with severe rate of mortality, at least 90% in some outbreaks. Their virions are filamentous and enveloped with enclosed negative-sense single-stranded RNA genome. The genome potentially expresses seven structural and nonstructural proteins. The replication cycle is complex consisting of multiple molecular processes and interactions with human-host factors and proteins. Due to high mortality rate of infection, the studies regarding cure is still infancy. This review covers the current understanding of the virus replication cycle and vaccine development, and herbal treatments to control Ebola covering the available literature on the subject.