Abstract
The notorious Ebola virus is associated with very high mortality rates; its rapid progression allowing little opportunity to develop natural immunity. However, one way to combat this disease is to vaccinate potential hosts and limit the spread of the disease. A recent report in Nature (30 November) by N.J. Sullivan et al. describes a vaccine strategy for Ebola virus infection in non-human primates using a combination of DNA vaccines and boosting with adeno-viral vectors that encode Ebola viral proteins. Challenge with a lethal dose of the Ebola virus resulted in 100% mortality in controls, whereas all vaccinated animals were asymptomatic for more than six months, demonstrating that it is possible to develop a preventive vaccine against Ebola virus infection in primates.
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