Abstract
The Ebf transcription factors play important roles in the developmental processes of many tissues. We have shown previously that four members of the Ebf family are expressed during mouse retinal development and are both necessary and sufficient to specify multiple retinal cell fates. Here we describe the changes in cell differentiation and retinal ganglion cell (RGC) projection in Ebf1 knockout mice. Analysis of marker expression in Ebf1 null mutant retinas reveals that loss of Ebf1 function causes a significant increase of Müller cells. Moreover, there is an obvious decrease of ipsilateral and retinoretinal projections of RGC axons at the optic chiasm, whereas the contralateral projection significantly increases in the mutant mice. These data together suggests that Ebf1 is required for suppressing the Müller cell fate during retinogenesis and important for the correct topographic projection of RGC axons at the optic chiasm.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
