Eaton lambert syndrome (LEMS) is a diagnostic challenge and stimulated single fiber electromyography (SSFEMG) is offering a great role in its early diagnosis

Abstract

LEMS is a presynaptic neuromuscular disorder, its early recognition is particularly important because of its strong association with small cell lung cancer (SCLC) and up to 50% are misdiagnosed. LEMS is often suspected according to symptoms. Electrodiagnostic approach includes Routine motor nerve conduction stimulation typically elicits a small amplitude compound muscle action potential (CMAP), with its increase >100% increment after After isometric contraction for 10 s, or high rate repetitive supramaximal stimulation, but what if it increases but not reaching 100%?