Abstract
Both enantiomers of the C7-C12 segment (5 and 6) of epothilones A and B (1 and 2) were effectively synthesized starting from the methyl (R)- and (S)-hydroxy-2-methylpropionates (3 and 4) using the Grignard cross-coupling reaction mediated by cuprous (I) salts in three steps.
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