Abstract
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2017 was held in St. John's, Newfoundland and Labrador, 28-30 September. Experts in radiation oncology, medical oncology, surgical oncology, and cancer genetics who are involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics in the management of gastric, rectal, and colon cancer, including ■ identification and management of hereditary gastric and colorectal cancer (crc);■ palliative systemic therapy for metastatic gastric cancer;■ optimum duration of preoperative radiation in rectal cancer-that is, short- compared with long-course radiation;■ management options for peritoneal carcinomatosis in crc;■ implications of tumour location for treatment and prognosis in crc; and■ new molecular markers in crc.
Highlights
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2017 was held in St
How can we identify patients and families that should be referred for genetic assessment for hereditary gastric cancer, and how should such patients be managed?
■■ The following situations were recognized as criteria that should trigger a referral for genetic testing for hereditary diffuse gastric cancer [level iii unless otherwise stated]: ■■ Diagnosis of 1 case of diffuse gastric cancer at less than 40 years of age ■■ Diagnosis of 2 gastric cancer cases regardless of age, at least 1 confirmed to be dgc ■■ Personal or family history of dgc and lobular breast cancer, 1 diagnosed at less than 50 years of age ■■ Bilateral lbc or family history of 2 or more cases of lbc diagnosed at less than 50 years of age ■■ In situ signet-ring carcinoma or pagetoid spread of signet-ring cells Each jurisdiction should, take into consideration local patterns
Summary
S.F. McGee md phd,* W. AlGhareeb md,* C.H. Ahmad md,† D. Armstrong md,† S. Babak md,* S. Berry md,* J. Biagi md,* C. Booth md,* D. Bossé md,‡ P. Champion md,§ B. Colwell md,|| N. Finn md,# R. Goel md,* S. Gray md,# J. Green phd,† M. Harb md,# A. Hyde md phd,* A. Jeyakumar md,|| D. Jonker md,* S. Kanagaratnam md,† P. Kavan md,** A. MacMillan ms,† A. Muinuddin md,* N. Patil md,|| G. Porter md,|| E. Powell md,† R. Ramjeesingh md phd,|| M. Raza md,# S. Rorke md,† M. Seal md,† F. Servidio-Italiano,* J. Siddiqui md,† J. Simms bn rn,† L. Smithson md,† S. Snow md,|| E. St-Hilaire md,# T. Stuckless md,† A. Tate md,† M. Tehfe md,** M. Thirlwell md,** E. Tsvetkova md,* M. Valdes md,* M. Vickers md,* K. Virik md,* S. Welch md,* C. Marginean md,* and T. Asmis md*
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