Abstract
This review shows the structure, mode of action, and actual epidemiological data about EAST1 toxin. It is a particularly intriguing bacterial toxin that may subvert multiple cellular processes to yield intestinal epithelial cell secretion. EAST1 toxin was first described in strains of EAggEC that were associated with persistent diarrhea primarily in developing world countries. Molecular organization, mobility, and data in literature are suggesting that EAST1 could be a transposon. The insertion sequences in Escherichia coli and some of the usual transposition mechanisms as well as regulation are reviewed. This review emphasizes the presence of the gene astA in EPEC, EAggEC, A-EPEC, ETEC, DAEC, EIEC, and in non-diarrheagenic E. coli. It also discusses here the presence of the astA gene in Salmonella spp. and future perspectives for understanding its role in diarrheal disease in both bacterial genera.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Venomous Animals and Toxins including Tropical Diseases
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
