Easily performed interval exercise induces to increase in skeletal muscle PGC-1α gene expression

Hiroaki Tanaka,Keisuke Shiose,Ryo Aoyagi,Seiya Ueno,Yoichi Hatamoto,Magdalena Jackowska,Yasuki Higaki

doi:10.15761/imm.1000293

Abstract

Easily performed interval exercise induces to increase in skeletal muscle PGC-1α gene expression

Highlights

Understanding the relationship between PGC-1α expression and exercise is important for developing therapeutic exercise programs focusing on the prevention of lifestyle diseases
The current study sought was to verify whether moderate intensity exercise at anaerobic threshold performed in intervals (AIE) leads to a PGC-1α mRNA expression increase similar to that observed in typical endurance exercise and high intensity interval exercise (HIE)
Maximal intensity interval exercise (MIE) was set at 245 ± 36 watts corresponding to 100% VO2max, High intensity interval exercise (HIE ) at 179 ± 23 watts corresponding to 74 ± 3% VO2max and moderate intensity at anaerobic threshold interval eaercise (AIE ) at 113 ± 14 watts corresponding to 48 ± 7% VO2max)

Summary

Introduction

Physical inactivity has resulted in a drastic increase in the prevalence of a number of chronic diseases [1]. There is evidence that low volume sprint interval exercise has similar effects to traditional endurance training, eliciting similar levels of PGC-1α and aerobic adaptation as typical endurance exercise training [4] [5]. It has been shown that practical aerobic interval exercise (10×1 min at 85-95% heart rate reserve interspersed with 1 min recovery) increases markers of skeletal muscle mitochondrial content and glucose transport capacity in sedentary middle-aged adults [6]. Short periods of higher-intensity interval exercise that have the same effect on PGC-1α expression as long durations of continuous exercise presents an attractive prospect. For participants in exercise therapy programs, who often suffer from illnesses or obesity and have low levels of fitness [e.g., sedentary middle-aged or elderly people], even the 85-95%HR exercise is hard to practice in the longer term. The current study sought was to verify whether moderate intensity exercise at anaerobic threshold performed in intervals (AIE) leads to a PGC-1α mRNA expression increase similar to that observed in typical endurance exercise and high intensity interval exercise (HIE)

Methods

Result

Findings

Discussion