Abstract
Cross-coupling reactions have been developed between C2-substituted 1-bromo-cyclobut-1-enes and Grignard reagents using two effective catalysts e.g. Fe(acac)3 and Ni(acac)2. The iron catalyst works in THF but requires NMP as the co-solvent, with the advantage of achieving cross-coupling reactions with alkyl Grignard reagents. The nickel catalyst was able to promote the reactions in THF without any additive and showed high reactivity with electron-rich aryl Grignard reagents. These catalyts gave various types of substituted cyclobutenes in good yields.
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