Early-Phase Recovery of Cardiorespiratory Measurements after Maximal Cardiopulmonary Exercise Testing in Patients with Chronic Obstructive Pulmonary Disease.

Marie Bellefleur,Antoine Cuvelier,Jérémy Coquart,Marie Netchitailo,Catherine Tardif,Jean-François Muir,David Debeaumont,Alain Boutry

doi:10.1155/2016/9160781

Abstract

Background. This study investigated respiratory gas exchanges and heart rate (HR) kinetics during early-phase recovery after a maximal cardiopulmonary exercise test (CPET) in patients with chronic obstructive pulmonary disease (COPD) grouped according to airflow limitation. Methods. Thirty control individuals (control group: CG) and 81 COPD patients (45 with “mild” or “moderate” airflow limitation, COPDI-II, versus 36 with “severe” or “very severe” COPD, COPDIII-IV) performed a maximal CPET. The first 3 min of recovery kinetics was investigated for oxygen uptake (O2), minute ventilation (), respiratory equivalence, and HR. The time for O2 to reach 25% (T1/4 O2) of peak value was also determined and compared. Results. The O2, , and HR recovery kinetics were significantly slower in both COPD groups than CG (p < 0.05). Moreover, COPDIII-IV group had significantly higher O2 and during recovery than COPDI-II group (p < 0.05). T1/4 O2 significantly differed between groups (p < 0.01; 58 ± 18 s in CG, 79 ± 26 s in COPDI-II group, and 121 ± 34 s in COPDIII-IV) and was significantly correlated with forced expiratory volume in one second in COPD patients (p < 0.001, r = 0.53) and with peak power output (p < 0.001, r = 0.59). Conclusion. The COPD groups showed slower kinetics in the early recovery period than CG, and the kinetics varied with severity of airflow obstruction.

Highlights

Patients with chronic obstructive pulmonary disease (COPD) are characterized by dyspnea and physical exercise intolerance, both of which impair the ability to participate in physical activities and lower the quality of life [1,2,3]
This study investigated respiratory gas exchanges and heart rate (HR) kinetics during early-phase recovery after a maximal cardiopulmonary exercise test (CPET) in patients with chronic obstructive pulmonary disease (COPD) grouped according to airflow limitation
BMI was significantly lower in COPDIII-IV compared with COPDI-II (p < 0.001)

Summary

Introduction

Patients with chronic obstructive pulmonary disease (COPD) are characterized by dyspnea and physical exercise intolerance, both of which impair the ability to participate in physical activities and lower the quality of life [1,2,3]. The cardiorespiratory data measured during the recovery period after CPET may provide indications of physical fitness. Oxygen uptake (V O2) and heart rate (HR) kinetics during recovery after physical exercise are indicators of physical fitness and cardiovascular health [6]. The V O2 kinetics during recovery after submaximal and maximal exercise is prolonged in heart failure patients and closely correlated with indicators of physical fitness (e.g., V O2peak). The half-time recovery of V O2 (i.e., T1/2V O2), which is the time required for a 50% fall in the V O2peak, was identified as an indicator of physical fitness in patients with cardiac disease [7]. This study investigated respiratory gas exchanges and heart rate (HR) kinetics during early-phase recovery after a maximal cardiopulmonary exercise test (CPET) in patients with chronic obstructive pulmonary disease (COPD) grouped according to airflow limitation. The COPD groups showed slower kinetics in the early recovery period than CG, and the kinetics varied with severity of airflow obstruction

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