Early-onset emphysematous pancreatitis indicates poor outcomes in patients with infected pancreatic necrosis.

Abstract

Emphysematous pancreatitis (EP) is a subtype of infected pancreatic necrosis (IPN) characterized by presence of gas in (peri)pancreatic necrosis. However, the impacts of EP on outcomes of IPN are still controversial. A prospective database of consecutive patients with IPN in a tertiary hospital was post-hoc analyzed. Patients were assigned to EP and non-EP groups to perform a comprehensive comparison. A total of 178 patients with IPN were enrolled and the overall mortality was 30.9%. EP accounted for 20.8% (n=37) of cases and was significantly associated with higher incidences of Escherichia coli (45.9 versus 18.4%, P=0.001) and Klebsiella pneumoniae (56.8 versus 33.3%, P=0.009) infection. There was scarcely any disparity in clinical characteristics and outcomes between IPN patients with and without EP. However, patients with early-onset EP defined as air bubble signs occurring within 2 weeks from disease onset were significantly older and have higher prevalence of history of diabetes, and they were also associated with significantly higher mortality (57.1 versus 8.7%, P=0.015) compared with late-onset patients. The clinical outcomes of EP might be like those of non-emphysematous infection. However, when EP occurs within 2 weeks from disease onset, it is highly lethal.