Abstract
Background 20-40% of reperfused ST-elevation acute myocardial infarction (STEMI) features microvascular obstruction (MO), which confers adverse prognosis. Different CMR sequences are commonly used to detect MO: first pass perfusion (FPP), early gadolinium enhancement (EGE), and late gadolinium enhancement (LGE). FPP and EGE are more sensitive than LGE for the detection of MO. However, only MO by LGE has been shown to confer prognostic information. It is unclear whether these three
Highlights
20-40% of reperfused ST-elevation acute myocardial infarction (STEMI) features microvascular obstruction (MO), which confers adverse prognosis
first pass perfusion (FPP) and early gadolinium enhancement (EGE) are more sensitive than late gadolinium enhancement (LGE) for the detection of MO
FPP imaging was performed during administration of 0.1 mmol/kg Gd-DTPA contrast. 4 minutes after contrast administration, EGE imaging was performed, followed by LGE imaging at both 10 minutes and at 20 minutes
Summary
20-40% of reperfused ST-elevation acute myocardial infarction (STEMI) features microvascular obstruction (MO), which confers adverse prognosis. Different CMR sequences are commonly used to detect MO: first pass perfusion (FPP), early gadolinium enhancement (EGE), and late gadolinium enhancement (LGE). FPP and EGE are more sensitive than LGE for the detection of MO. Only MO by LGE has been shown to confer prognostic information. Cardiology, Multidisciplinary Cardiovascular Research Centre & Leeds Institute of Genetics, Health and Therapeutics, Leeds, UK methods detect separate pathologies, or whether differences in MO appearances merely reflect contrast distribution over time. We aimed to determine how appearances between these methods are related
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