Abstract
Early virological response to HIV treatment: can we predict who is likely to experience subsequent treatment failure? Results from an observational cohort study, London, UK
Highlights
For people living with HIV, the first antiretroviral treatment (ART) regimen offers the best chance for a good virological response
For people living with HIV, the first antiretroviral therapy (ART) regimen offers the best chance for a good virological response, which, if achieved, minimizes the chance of developing resistance [1,2]
Several studies conducted to evaluate predictors of virological response to ART in treatment-naive patients have found an association between higher pre-ART HIV RNA viral load (VL) and increased risk of treatment failure by 6–12 months [3,4,5,6,7,8,9]
Summary
For people living with HIV, the first antiretroviral treatment (ART) regimen offers the best chance for a good virological response. Several studies conducted to evaluate predictors of virological response to ART in treatment-naive patients have found an association between higher pre-ART HIV RNA viral load (VL) and increased risk of treatment failure by 6–12 months [3,4,5,6,7,8,9]. A few studies have evaluated the association between VL levels in the first 1–2 months of ART and subsequent virological response [3,8,9] Most of these studies considered the earlier ART calendar period (pre-2000), and results may not be applicable to those starting ART today, with newer, better tolerated or more effective drugs
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