EARLY SMALL CELL CARCINOMA OF THE ESOPHAGUS ASSOCIATED WITH WERNICKE-KORSAKOFF SYNDROME -REPORT OF A CASE-

Abstract

A case of early small cell carcinoma of the esophagus which was detected during treatment for Wernicke-Korsakoff syndrome due to vitamin B1 deficiency and was treated by operation with adjuvant chemotherapy, is reported. A 53-year-old man, who had been receiving therapy for Wernicke-Korsakoff syndrome at the department of internal medicine in our hospital, was point out having 2+O-IIc type of esophageal cancer on upper gastrointestinal series for screening purpose. His previous medical history was unknown. The patient was transferred to the department, and underwent a right thoracolaparotomic subtotal esophagectomy, retrosternal gastric tube reconstruction, and R-II. Histopathologically, the 0-Ilc type lesion was moderately differentiated squamous cell carcinoma with the invasion depth of mm3, and the 2 type lesion was composed of small cell type of poorly differentiated carcinoma with ythe invasion depth of sm3. Otherwise, n (-), lyl, and v2 were rated. After the operation adjuvant chemotherapy with CDDP and 5 FU was conducted. There has been no sign of recurrence, as of 11 months after the operation.