Abstract
Nineteen male rabbits were given sc injections of cadmium chloride at dose levels of 15, 6 and 1.5 mg Cd/kg/day. Body weight, renal function and urinary excretion of enzymes were periodically examined. Loss of body weight and increase of urinary excretion of protein, alkaline phosphatase and acid phosphatase were found to be early warning signs suggestive of renal injuries. Temporal dysfunction of distal tubules, accompanied by warning signs, and renal dysfunction appeared later. Signs of intoxication were found to be closely correlated with the accumulated dose of cadmium. The cumulative median lethal dose was estimated to be 40–44 mg Cd/kg. Stop-flow analysis, performed at the end of successive cadmium administrations, revealed proximal tubular dysfunction as well as glomerular and distal tubular dysfunction.
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