Abstract

A blinded comparison of parental and clinical observations of the behavior of 26 autistic children (23 boys and 3 girls) younger than age 48 months is reported from the Vanderbilt University School of Medicine, Nashville, TN, and The Children’s Mercy Hospital, Kansas City.

Highlights

  • A fatal hepatic failure in a 3 year-old girl with myoclonic epilepsy after 3 months of treatment with valproate (VPA) is reported from Hopital d'Enfants, Marseilles, and Hopital des Enfants-Malades, Paris, France

  • Vomiting as an ictal phenomenon is controversial and difficult to distinguish from migraine. In these patients with previous evidence of occipital epileptiform EEG discharges, visual symptoms followed by automatisms and vomiting appeared more likely to result from temporal lobe ictal involvement than a migraine secondary to an occipital seizure

  • The lateralization of the ictal discharge to the right hemisphere has previously been reported in 13 children with the diagnosis of ictus emeticus. (Kramer RE et al, 1988)

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Summary

Introduction

A fatal hepatic failure in a 3 year-old girl with myoclonic epilepsy after 3 months of treatment with valproate (VPA) is reported from Hopital d'Enfants, Marseilles, and Hopital des Enfants-Malades, Paris, France. In these patients with previous evidence of occipital epileptiform EEG discharges, visual symptoms followed by automatisms and vomiting appeared more likely to result from temporal lobe ictal involvement than a migraine secondary to an occipital seizure. The lateralization of the ictal discharge to the right hemisphere has previously been reported in 13 children with the diagnosis of ictus emeticus.

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Conclusion
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