Abstract
Background - Hypoxic-ischemic encephalopathy (HIE) continues to represent a significant burden of neonatal morbidity and mortality worldwide. Therapeutic hypothermia improves the neurodevelopmental outcome in 1 out of 8 infants when initiated within 6 hours of life. However, the clinician lacks an objective algorithm for predicting the severity of brain injury. We hypothesized that the concentrations of two neonatal brain injury biomarkers, Ubiquitin C-terminal hydrolase L1 (UCH-L1) and Glial fibrillary acidic protein (GFAP), will predict the subjective magnitude of brain injury and the volume of injury in the cortex, deep grey matter …
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