Abstract
Levels of peripheral blood progesterone weremeasured in rats hypophysectomized and autografted on the day of sperm detection (day 1 of pregnancy) and sacrificed at 24 h intervals over a period of 10 days. After an initial delay, progesterone levels reached 3.43 ± 0.80 <i>µ</i>g/100 ml at 48 h after autografting, which is comparable to the value on day 6 of normal pregnancy. Progesterone titres reached a level of 8.46 ± 0.98 <i>µ</i>g/100 ml by the 6th day of transplantation and showed no significant change for the duration of the experiment. Although rats were pregnant at the time of autografting, only resorbing implantation sites were noted in some of the rats at autopsy. The results of this study indicate that an ectopically placed pituitary achieves functional restitution within 24 to 48 h following transplantation. Although progesterone levels were equal to or greater than those found in normal pregnancy, the transplanted pituitary <i>per se </i>was unable to maintain pregnancy.
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