Abstract
Tikkanen et al1 propose a significant and independent association between inferior/lateral ECG early repolarization (ER) patterns and sudden cardiac death (SCD) during an acute coronary event—an observation mainly based on the inclusion of ER pattern in multivariate predictive models for the occurrence of SCD, even after adjustment for several variables with usual prognostic value. Recent/new investigation has claimed a role for ER in the pathogenesis of idiopathic ventricular fibrillation or cardiac death in the community-based general population2 and in patients with ischemic or nonischemic chronic heart failure.3 ER (in particular, notching in the inferior leads) has also been shown to increase the risk of life-threatening ventricular arrhythmias in patients with coronary artery disease, even …
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