Early predictors to differentiate primary from secondary dengue infection in children

Abstract

Aim: We aimed to analyze the early predictors to differentiate primary from secondary dengue infection and the severity of liver involvement with reference to mortality. Materials and Methods: This prospective study was conducted on 200 children having acute febrile illness between 3 months to 15 years age group. One hundred and five serologically confirmed dengue patients were included in the study and classified into primary and secondary dengue infection. Liver function tests (LFTs) and electrolytes were analyzed, and the hepatic dysfunction was correlated to the severity of the disease. Results: Of the 105 serologically confirmed dengue, 62 (59%) were primary and 43 (41%) were secondary dengue infection. Primary dengue infection was more common in Conclusion: Abnormal LFTs can be a marker to predict disease severity, but may not differentiate primary from secondary dengue infection. Occurrence of hyponatremia and thrombocytopenia may identify children likely to have secondary dengue.