Early prediction of infarct size by ultra-fast online assessment of systolic left ventricular longitudinal function

Abstract

Summary TMAD provides the possibility for the assessment of global systolic longitudinal function in patients with STEMI and correlates well with the extent of myocardial infarction, determined by LGE-CMR. TMAD is a novel, ultra-fast, sensitive and easily reproducible parameter and therefore a valuable predictor for the extent of myocardial infarction. Further prospective studies have to be conducted to test TMAD as a promising tool for clinical routine. Background In clinical routine, fast assessment of infarct size is crucial for accurate early risk assessment. Global left ventricular (LV) longitudinal strain is associated with infarct size and outcome. The measurement of global longitudinal function is often dependent on image quality, experience of the observer and it is time-consuming. We investigated global systolic LV longitudinal function with TMAD (tissue motion annular displacement), a novel method based on a 2-D strain tissue tracking algorithm, and compared it with contrast-enhanced magnetic resonance imaging (CMR). The aim of the study was to investigate whether TMAD is able to diagnose LV infarct size early after successful revascularization in patients with first acute ST-segment elevation myocardial infarction (STEMI). Methods